A running list of players ejected in the 2021 season.
| Week | Game | Player | Pos | Team | Reason | Time | Referee | |
|---|---|---|---|---|---|---|---|---|
| 1. | 1 | CLE-KC | Ronnie Harrison | SS | CLE | Fighting | 5:08/1Q | Vinovich |
| 2. | 2 | LAR-IND | Kenny Young | LB | LAR | Contact with an official | 4:36/3Q | Smith |
| 3. | LV-PIT | Trai Turner | G | PIT | Spitting | 11:15/4Q | Boger | |
| 4. | 5 | NYG-DAL | Kadarius Toney | WR | NYG | Throwing a punch | 6:24/4Q | Hussey |
| 5. | 7 | CHI-TB | Bilal Nichols | DT | CHI | Throwing a punch | 2:12/3Q | Kemp |
| 6. | 9 | SEA-KC | DK Metcalf | WR | SEA | Fighting | 1:23/4Q | Allen |
| 7. | 11 | SF-JAX | Rayshawn Jenkins | FS | JAX | Throwing a punch | 9:58/2Q | Torbert |
| 8. | 12 | LV-DAL | Roderick Teamer | S | LV | Fighting | 13:00/3Q | Hochuli |
| 9. | Kelvin Joseph | CB | DAL | |||||
| 10. | 14 | DAL-WAS | La’el Collins | OT | DAL | Throwing a punch | 10:15/4Q | Kemp |
| 11. | 15 | NE-IND | Kyle Dugger | SS | NE | Fighting | 5:44/3Q | Cheffers |
| 12. | Michael Pittman | WR | IND | |||||
| 13. | MIN-CHI | Eric Kendricks | LB | MIN | Helmet-to-helmet contact on sliding QB | 9:50/4Q | Novak |
